The resulting acyl-carnitine is carried by the enzyme carnitine-acylcarnitine translocase-to ext. side of the membrane. Here, with the participation of carnitine acyltransferase II also built into the membrane occurs resynthesis KoSCOR, carnitine and freed again transferred through periplazmatich. space for ext. side of the membrane. T. arr. By carnitine fatty to-you are within the scope of the oxide. Chem. carnitine synthesis is usually carried out by treating epichlorohydrin with trimethylamine sequentially and an alkali metal cyanide, hydrolyzing the resulting nitrile with 3-hydroxy-4-to-you trimetilaminomaslyanoy to carnitine. Splitting into optical instruments. isomers is performed at the stage of the nitrile. Al. synthesis pathway of L-carnitine-stereospecific. recovery via a yeast-octyl-3-oxo-4 to L-hlorbutirata octyl-3-hydroxy-4-hlorbutirata, interaction. last and last with trimethylamine. hydrolyzing the resulting product. Carnitine is used in medicine in the form of D, L-and L-karnitinhlorida as nonsteroidal anabolic. Wed-wa. Lit .: A. Lehninger, Principles of Biochemistry, Acad. from Eng., vol. 2, Moscow, 1985, p. 554-55; Carnitine biosynthesis and function. Minisymposium, St. Louis, Missouri, June 4, 1981, "Federal. Proceeding", 1982, v. 41, № 12, p. 2840-42. A. M. Jurkiewicz.
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