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Category Pharmaceutics  

Ethosuximide


2017-12-08 00:00:00

Ethosuximide Ethosuximidum. 3-Ethyl-3-methylpyrrolidine-2,5-dione or a-ethyl-a-metilsuktsinimid. Synonyms: Asamid, Piknolepsin, Ronton, Suksilep, Etomal, Aethosuximid, Asamid, Ethymal, Etomal, Pemalim, Petinimid, Pyknolepsin, Ronton, Succimal, Suxilep, Zarontin and others. It has anticonvulsant activity, exercise, like Trimetin, the small forms epilepsy. Also effective in myoclonic seizures. Somewhat less toxic than Trimethadione. Appointed interior taken with food. The initial daily dose for children 0.25 g, for older children and adults-0.25-0.5 g per day with gradual increase in dose for adults and 0.75-1 g per day in 3-4 admission. The drug has analgesic effect of trigeminal neuralgia sm.Karbamazepin, but slightly less effective than carbamazepine. Administered in a dose of 0.25 g, gradually increasing the dose up to 0.5-1 g per day. The maintenance dose of 0.25 g per day. Possible side effects: gastrointestinal disorders, in rare cases-headache, dizziness, skin rash, photophobia. There may be symptoms of parkinsonism. Not exclude the possibility of neutropenia, agranulocytosis, albuminuria. In the treatment process to produce blood and urine tests. Keep in mind that the drug can provoke the appearance of large seizures of epilepsy. Ethosuximide crosses the placental barrier in the milk of nursing women. Therefore, pregnant and breastfeeding is not recommended to prescribe the drug. Release form: called "Suksilep" available in capsules of 0.25 g in a package of 100 and 150 pieces in a solution containing 100 ml of 5 g of the preparation, 25 g of glycerol and 25 ml of water and alcohol mixture in vials of 50 g; 15 drops of a solution containing 0.25 g of ethosuximide. Storage: List B.




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