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Category Pharmaceutics  

Gemfibrozil


2017-12-08 00:00:00

Gemfibrozil Gemfibrozil *. 5-2,5-Dimethylphenoxy-2,2 dimetilpentanoevaya acid. Synonyms: Gevilon, Dopur, Gevilon, Nipolixan, Lipigem, Lipozid, Lopid, Normolip et al. Obtained as a result of the search clofibrate derivatives having less toxicity. Gemfibrozil turned low toxicity and yet highly effective hypolipidemic agent reducing the content of VLDL in blood of patients with hypertriglyceridemia, no treatment reagiruyushih diet and other lipid-lowering drugs. Furthermore, it increases the concentration of HDL. Gemfibrozil with fast and almost completely absorbed by ingestion. The peak concentration in the blood observed after 1-2 hours after administration. Provided mainly kidneys as glucuronides. Assign an adult to 0.3-0.45 g, 2 times a day for 30 minutes before breakfast and dinner. The full therapeutic effect occurs after 3-4 weeks. Prescribed to patients with hypertriglyceridemia when resistance to therapeutic diet and other lipid-lowering agents. When giperhilomikronemii due to deficiency of lipoprotein lipase family, the drug is ineffective. Gemfibrozil is generally well tolerated. Possible gastrointestinal disorders abdominal pain, nausea, diarrhea .. In rare cases, a small anemia, leukopenia. Similar but less clofibrate may promote the formation of gallstones. Contraindicated in patients with gallbladder disease. The drug is not prescribed to pregnant women and children. Potentiates the action of anticoagulants. Method of issuance: capsules to 0.3 g 300 mg; tablets, coated white, 0.45 g




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